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疟疾引起贫血除疟原虫直接破坏红细胞外,尚有免疫因素及疟原虫代谢产物引起的溶血,网状内皮系统功能亢进和骨髓造血功能抑制亦有作用。我们认为感染小鼠(特别是慢性期)脾脏增大,吞噬红细胞总量增加,为贫血原因之一。急性感染小鼠溶血严重,但其原因与免疫因素、疟原虫代谢产物和脾细胞毒作用无明显关系。
Malaria-induced anemia In addition to malaria parasites direct destruction of red blood cells, there are immune factors and plasmodial malaria metabolites caused by hemolysis, reticuloendothelial system hyperthyroidism and inhibition of bone marrow hematopoietic function also has a role. We believe that infected mice (especially chronic phase) increased spleen, phagocytosis increased the total amount of red blood cells, one of the causes of anemia. Acute infection of mice hemolysis serious, but the reasons and immunological factors, Plasmodium metabolites and spleen cytotoxicity no significant relationship.