前言原发性高血压的病因、发病机理和病理生理极为错综复杂,涉及许多方面,其中肾素—血管紧张素系统(Renin—Angiotensin—system,RAS)是探索较多的因素之一,但分歧也不少,故仍需进一步探讨。自从Brunner等1972年提出肾素是高血压病心血管损害的一个危险因子以来,至今也仍有争论。这些研究大多是单因子的,而与儿茶酚胺、醛固酮等多因子作同步测定和逐步回归分析则很少报道。儿茶酚胺在高血压病的分泌状况至今各家研究结果不一,血液流变性在高血压病不同时期的变化以及影响全血粘度的多因子的逐步回归分析也研究甚少。我们为了探讨高血压病发生发展中多因子的影 Introduction The etiology, pathogenesis and pathophysiology of essential hypertension are extremely complex and involve many aspects. Renin-angiotensin system (RAS) is one of the more explored factors, but the differences are also Many, so still need to be further explored. Since Brunner et al. Proposed in 1972 that renin is a risk factor for cardiovascular damage in hypertension, there is still controversy so far. Most of these studies are single-factor, and with catecholamines, aldosterone and other factors for simultaneous determination and stepwise regression analysis are rarely reported. Catecholamine secretion in hypertension so far the results of different studies, blood rheology in different periods of hypertension and the impact of the whole blood viscosity of the multi-factor regression analysis is also rarely studied. We in order to explore the occurrence and development of hypertension multi-factor shadow