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目的探讨胰岛素及其受体、胰岛素样生长因子I及其受体在多囊卵巢综合征患者子宫内膜的表达特点。方法利用免疫组化实验技术分析INS、INS-R、IGF-I和IGF-IR在多囊卵巢综合征和非多囊卵巢综合征不孕症患者子宫内膜中的表达情况,对结果进行图像分析,并利用SPSS10.0软件进行统计学分析,比较各组间的差异。结果1.多囊卵巢综合征患者子宫内膜IGF-I和INS-R表达水平明显高于对照组,差异有显著性(P<0.01)。其中多囊卵巢综合征中子宫内膜增生症患者的IGF-I和INS-R表达水平高于多囊卵巢综合征组增殖期患者,差异有显著性(P<0.05)。2.IGF-IR和INS在多囊卵巢综合征患者与对照组子宫内膜的表达水平无明显差异(P>0.05)。结论多囊卵巢综合征患者子宫内膜异常增生可能与局部IGF-I和INS-R表达异常有关。
Objective To investigate the expression of insulin and its receptor, insulin-like growth factor I and its receptor in patients with polycystic ovary syndrome. Methods Immunohistochemistry was used to analyze the expression of INS, INS-R, IGF-I and IGF-IR in endometrium of women with polycystic ovary syndrome and non-PCOS infertility. The results were analyzed by image Analysis, and the use of SPSS10.0 software for statistical analysis, comparing the differences between groups. The expression of IGF-I and INS-R in endometrium of patients with PCOS was significantly higher than that of the control group (P <0.01). The expression of IGF-I and INS-R in polycystic ovary syndrome patients with endometrial hyperplasia was higher than that in PCOS patients (P <0.05). The expression of IGF-IR and INS in endometrium of PCOS patients and control group had no significant difference (P> 0.05). Conclusion The abnormal proliferation of endometrium in patients with polycystic ovary syndrome may be related to the abnormal expression of local IGF-I and INS-R.