心房颤动(Af)为最常见的心律失常,常与心血管发病率和死亡率相关,Af常常需要触发机制诱发及有利的电生理或解剖底物维持,近年对触发Af底物发展这一新的治疗策略产生了兴趣,基础和临床试验资料提示调节肾素-血管紧张素-醛固酮系统(RAAS)或许可减少心脏重塑和Af,现对RAAS抑制剂治疗和预防Af的机制、基础和临床研究结果以及正在进行的临床研究等进行简要综述。 Atrial fibrillation (Af) is the most common arrhythmia and is often associated with cardiovascular morbidity and mortality. Af often requires triggering mechanisms and favorable electrophysiological or dissection substrate maintenance. In recent years, this new Therapeutic strategies have generated interest in basic and clinical trials suggesting that the modulation of the renin-angiotensin-aldosterone system (RAAS) may reduce cardiac remodeling and Af, and that RAAs inhibitors are currently being used to treat and prevent Af Research findings and ongoing clinical studies are briefly reviewed.