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目的观察度洛西汀联合甲钴胺治疗痛性糖尿病周围神经病(DPN)变患者血清脑源性神经营养因子(BDNF)、白细胞介素-6(IL-6)水平的影响。方法将200例痛性糖尿病周围神经病患者随机分为研究组及对照组各100例。研究组采用度洛西汀与甲钴胺联合治疗,对照组采用甲钴胺治疗,2组均治疗4周。比较2组患者治疗前和治疗后1周、2周及4周时的血清BDNF、IL-6水平的变化。结果治疗2周和4周时,2组血清BDNF水平均高于治疗前,IL-6水平均低于治疗前,差异均有统计学意义(P<0.05);且研究组血清BDNF水平均高于对照组,IL-6水平低于对照组,差异均具有统计学意义(P<0.05)。结论度洛西汀联合甲钴胺治疗痛性DPN可有效调节血清BDNF、IL-6的水平,能有效改善患者的病情,疗效优于单纯使用甲钴胺。
Objective To observe the effects of duloxetine and mecobalamin on the levels of serum brain-derived neurotrophic factor (BDNF) and interleukin-6 (IL-6) in patients with painful diabetic peripheral neuropathy (DPN). Methods 200 cases of diabetic peripheral neuropathy were randomly divided into study group and control group of 100 cases. The study group was treated with duloxetine and mecobalamin, the control group was treated with mecobalamin, and the two groups were treated for 4 weeks. The levels of serum BDNF and IL-6 in two groups before and after treatment were compared at 1 week, 2 weeks and 4 weeks after treatment. Results At 2 weeks and 4 weeks after treatment, the levels of serum BDNF in both groups were significantly higher than those before treatment, and the levels of IL-6 in serum were lower than those before treatment (P <0.05) In the control group, the level of IL-6 was lower than that of the control group, the difference was statistically significant (P <0.05). Conclusion Duloxetine and mecobalamin treatment of painful DPN can effectively regulate serum levels of BDNF and IL-6, and can effectively improve the patient’s condition. The curative effect is better than mecobalamin alone.