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目的探讨妊娠合并甲状腺功能亢进症的诊断、治疗及母儿预后。方法回顾性分析2011年2月至2015年9月郑州大学第一附属医院收治的64例妊娠合并甲亢患者的资料,以58例正常孕妇作为本次研究的对照组,同时在研究中对病情控制组以及病情未控制组的两组患者进行对比分析,以明确这两组被观察人员的甲亢疾病活动,此外,比较三组的产科并发症、胎儿结局情况。结果 1甲状腺激素水平:控制组血清TSH、FT3、FT4与未控制组比较(P<0.05),有统计学差异。2孕产妇不良结局比较:妊娠期高血压、妊娠期糖尿病、胎盘早剥、甲亢性心脏病、甲亢危象、流产、引产、早产的发生率控制组显著低于未控制妊娠组(P<0.05),有统计学差异,对照组与控制组无统计学差异。3围产儿不良结局比较:胎儿宫内窘迫、胎儿宫内生长受限(IUGR)、新生儿窒息、死胎的发生率控制组显著低于未控制妊娠组(P<0.05),以上分析的数据存在统计学上的具体差异,而围产儿不良结局的发生率在控制组与对照组见无统计学差异。结论妊娠合并甲亢患者只有选择合适的时机受孕、早期诊断、积极治疗,并严密监测母儿情况,适时适式终止妊娠,才能获得良好的妊娠结局。
Objective To investigate the diagnosis and treatment of pregnancy complicated with hyperthyroidism and maternal and child prognosis. Methods The data of 64 cases of pregnancy complicated with hyperthyroidism admitted from the First Affiliated Hospital of Zhengzhou University from February 2011 to September 2015 were retrospectively analyzed. Fifty-eight normal pregnant women were used as the control group in this study. At the same time, Group and uncontrolled patients were compared between the two groups to identify the two groups were observed hyperthyroidism disease activity, in addition, the comparisons of the three groups of obstetric complications, fetal outcome. Results 1 Thyroid hormone levels: the control group serum TSH, FT3, FT4 compared with the uncontrolled group (P <0.05), there was a significant difference. 2 maternal adverse outcomes: gestational hypertension, gestational diabetes, placental abruption, hyperthyroidism heart disease, hyperthyroidism crisis, abortion, induction of labor, the incidence of preterm birth control group was significantly lower than the uncontrolled pregnancy group (P <0.05 ), There is statistical difference, there is no significant difference between control group and control group. 3 Comparison of adverse outcomes in perinatal children: The incidence of fetal distress, fetal growth restriction (IUGR), neonatal asphyxia and stillbirth in the control group was significantly lower than that in the uncontrolled pregnancy group (P <0.05). The above data existed Statistical differences, and the incidence of adverse outcomes in perinatal children in the control group and the control group, no significant difference. Conclusion Pregnancy complicated with hyperthyroidism patients only choose the right time to conceive, early diagnosis, active treatment, and close monitoring of maternal and child, timely and appropriate termination of pregnancy, in order to get a good pregnancy outcome.