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目的：观察稳态噪声、脉冲噪声与两者协同作用下对豚鼠内耳的损伤。方法：正常豚鼠９６只，分为３组，（１）稳态组：接受１１０ｄＢＡ稳态噪声４小时，连续３天；（２）脉冲组：接受脉冲噪声峰压值为１６５ｄＢＡ的爆震１０发；（３）稳态＋脉冲组：暴露于稳态噪声３天后休息２小时再接受脉冲噪声１０发。测豚鼠皮层诱发电位及观察耳蜗火棉胶包埋标本、铺片标本。结果：３组分别噪声刺激后对豚鼠听阈及内耳形态学均有影响，以稳态组最轻，稳态＋脉冲组最重。结论：在噪声环境中工作的艇员应加强对内耳的防护，以减少爆震性耳聋的发生。
OBJECTIVE: To observe the steady-state noise, impulsive noise and their synergistic effect on the inner ear of guinea pigs. Methods: 96 normal guinea pigs were divided into 3 groups. (1) Steady state group: Steady state noise of 110 dBA was received for 4 hours for 3 consecutive days; (2) Pulsed group: 10 detonations with impulse noise peak pressure of 165 dBA ; (3) Steady state + pulse group: After exposure to steady-state noise, rest for 2 hours and then receive 10 pulses of impulse noise. Test guinea pig cortical evoked potentials and observe the cochlear fire cotton glue embedded specimens, the film specimens. Results: After noise stimulation, the hearing threshold and inner ear morphology of guinea pigs were all affected by three groups of noise, the lightest in the steady state group and the heaviest in the steady state + pulse group. Conclusion: The crew working in a noisy environment should strengthen the protection of the inner ear to reduce the detonation deafness.