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抗痫药已广泛用于癫痫和非癫痫病人的治疗,但对药物导致中毒的原因则知之甚少。为了明确中毒的可能因素。作者对1979～1985年服用苯妥英钠(PHT)、卡马西平(CBZ)、乙琥胺(ESM)、苯巴比妥(PB)、扑痫酮(PRM)和丙戊酸(VPA)有中毒的病人作了回顾性研究。中毒标准至少出现下列表现之一者作为中毒的标准:①意识水平降低或精神错乱;②眼球运动(复视、振动幻视、原发性注视性眼震、斜视),前庭(眩晕、指误)或小脑功能障碍(构音障碍、躯干或肢体的共济失调);③抗痫药血浓度降至治疗范围
Antiepileptic drugs have been widely used in the treatment of epilepsy and non-epileptic patients, but little is known about the causes of drug-induced poisoning. In order to clarify the possible causes of poisoning. The author was poisoned by taking PHT, CBZ, ESM, PB, PRM and VPA from 1979 to 1985, Of patients made a retrospective study. Poisoning criteria at least one of the following manifestations as the standard of poisoning: ① reduce the level of consciousness or confusion; ② eye movement (diplopia, Vibration Vision, primary gaze nystagmus, strabismus), vestibular ) Or cerebellar dysfunction (dysarthria, ataxia of the trunk or limb); ③ blood concentration of antiepileptic drug dropped to the therapeutic range