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观察不同剂量溃结灵胶囊治疗溃疡性结肠炎豚鼠模型 ,阐述溃结灵胶囊的治疗机理。方法 取 3～ 4周龄健康豚鼠 ,腹腔戊巴比妥麻醉 ,插管洗肠后注入 7%冰乙酸造模。分为正常对照组、造模组、阳性对照组、溃结灵高剂量组和溃结灵低剂量组。服药 7d。称体重 ,肉眼和组织切片观察结肠溃疡面溃疡数、结肠水肿面积及测定血清中 IL- 2水平。结果 豚鼠造模后血清IL - 2水平下降 ,体重减轻 ,结肠壁溃疡形成。用溃结灵灌服后上述指标明显恢复。结论 溃结灵胶囊能提高溃疡性结肠炎豚鼠模型血清 IL- 2水平 ,增加体重 ,修复和缩小结肠粘膜溃疡、水肿面积
Observe different doses of Kuijieling capsule in the treatment of ulcerative colitis in guinea pigs, and expound the therapeutic mechanism of Kuijieling capsule. Methods Three to four-week-old healthy guinea pigs were anesthetized with intraperitoneal pentobarbital. After intubation and intestine instillation, 7% glacial acetic acid was injected. Divided into normal control group, modeling group, positive control group, high dose group of Kuijieling and low dose group of Kuijieling. Taking medication 7d. Weight, gross and tissue sections were used to observe the number of colon ulcer ulcers, colon edema area, and serum IL-2 levels. Results After guinea pigs were established, serum IL-2 levels decreased, body weight decreased, and ulceration of colonic wall was formed. The above indicators were significantly restored after the administration of Kuijie Ling. Conclusion: Kuijieling capsule can improve serum IL-2 level in guinea pigs with ulcerative colitis, increase body weight, and repair and reduce the area of ulceration and edema of colon mucosa.