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Sm16/Sj16最早是从血吸虫的尾蚴分泌物中分离得到一种分泌蛋白,而尾蚴为血吸虫生活史中重要的感染期,Sm16/Sj16的分泌可减轻尾蚴感染宿主时引起的炎症反应。近年对血吸虫Sm16/Sj16分子的研究发现该分子参与下调血吸虫尾蚴感染宿主过程中炎症介质的表达水平,表现出了显著的抗炎作用,因而Sm16/Sj16分子可被制备为抗炎制剂应用于临床疾病的治疗。关于血吸虫Sm16/Sj16分子的文献报道众多,但血吸虫感染皮肤阶段涉及的具体的免疫调节机制至今尚未明确。本文针对血吸虫Sm16/Sj16分子的基因表达、体内外生物学功能的研究进展进行综述。
Sm16 / Sj16 was first isolated from the secretions of cercariae of Schistosoma japonicum, and cercariae was an important infection in the life cycle of Schistosoma japonicum. The secretion of Sm16 / Sj16 could reduce the inflammatory reaction induced by cercariae infected host. In recent years, the study on the Sm16 / Sj16 molecule of Schistosoma japonicum has found that the molecule is involved in down-regulating the expression of inflammatory mediators during host infection of Schistosoma japonicum and shows a significant anti-inflammatory effect. Therefore, the Sm16 / Sj16 molecule can be prepared as an anti-inflammatory agent for clinical use Disease treatment. There are many reports about Schistosoma japonicum Sm16 / Sj16 molecule, but the specific immunomodulatory mechanism involved in the skin stage of schistosoma infection is still unclear. In this paper, the gene expression of Schistosoma japonicum Sm16 / Sj16 and the progress of biological function in vivo and in vitro were reviewed.