口腔癌是头颈部最常见的肿瘤,患者多伴有焦虑或抑郁情绪,而情绪异常又是癌症发生发展的“催化剂”和预后的预报器。口腔癌的情绪异常与下丘脑-垂体-肾上腺(HPA)轴调节紊乱应有一定关联性。本文提示以神经内分泌重要环节——HPA轴调节紊乱为重要切入点,探讨口腔癌情绪异常的生物学机制,可为口腔癌的情绪异常及其干预措施的机制研究提供新思路,具有重要意义。 Oral cancer is the most common tumor in the head and neck. Patients are often accompanied by anxiety or depression, which is a predictor of cancer development and prognosis. Oral cancerous disorders and hypothalamic-pituitary-adrenal (HPA) axis disorders should have a certain relationship. This paper suggests that the important part of neuroendocrine - HPA axis regulation disorder as an important entry point to explore the biological mechanism of oral cancer anomalies, oral cancer for the emotional anomalies and mechanisms of intervention provides new ideas, is of great significance.