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目的:研究人工肝支持系统对重型肝炎的临床疗效。方法:对26例重型肝炎患者根据病情分别选择血浆置换、血浆置换联合血液滤过等人工肝支持方法进行治疗,比较治疗前后患者临床症状、肝功能、肾功能、血氨、凝血功能等指标。结果:治疗后患者症状明显缓解,血清总胆红素、总胆汁酸、血氨下降,凝血酶原时间缩短,凝血酶原活动度上升(P<0.01)。结论:人工肝支持系统能显著改善重型肝炎患者临床症状及生化指标,提高近期存活率。
Objective: To study the clinical effect of artificial liver support system on severe hepatitis. Methods: Twenty-six patients with severe hepatitis were treated by artificial liver support, such as plasma exchange, plasma exchange and hemofiltration. The clinical symptoms, liver function, renal function, blood ammonia, coagulation function and other indexes were compared before and after treatment. Results: After treatment, the symptoms of patients were relieved. The total serum bilirubin, total bile acid, blood ammonia decreased, prothrombin time shortened and prothrombin activity increased (P <0.01). Conclusion: Artificial liver support system can significantly improve the clinical symptoms and biochemical indexes of patients with severe hepatitis and improve the short-term survival rate.