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①目的 探讨山东沿海地区甲状腺肿的患病现状并对尿碘水平进行调查。②方法 采用随机分层整群抽样法 ,对山东沿海地区烟台、威海、日照和青岛甲状腺肿患病情况进行调查 ,并以五莲县作为对照。③结果沿海地区甲状腺肿的患病率为 9.4 9% ,明显高于五莲县 (4 .2 7% ) (u =6 .74 ,P <0 .0 1)。沿海地区甲状腺肿抗甲状腺过氧化物酶抗体 (TPOAb)、球蛋白抗体 (TGAb)和尿碘明显高于对照组 (t=2 .15～ 2 .93,P <0 .0 5、0 .0 1)。尿碘与TGAb呈正相关 (r=0 .2 4 ,P <0 .0 1)。④结论 山东沿海地区甲状腺肿和尿碘浓度有明显的区域分布 ,居民离海越近 ,甲状腺肿的患病率也越高。离海较近地区居民应适当减少高碘物质的摄入。
Objective To investigate the prevalence of goiter in Shandong coastal areas and to investigate urinary iodine levels. Methods The random stratified cluster sampling method was used to investigate the prevalence of goiter in Shandong coastal areas of Yantai, Weihai, Rizhao and Qingdao and Wulian County was used as a control. Results The prevalence of goiter in coastal areas was 9.49%, significantly higher than that in Wulian County (4.27%) (u = 6.74, P <0.01). In the coastal areas, the levels of thyroid goat anti-thyroid peroxidase antibody (TPOAb), globulin antibody (TGAb) and urinary iodine were significantly higher than those in the control group (t = 2.15-2.93, P <0.05,0.0 1). Urinary iodine and TGAb was positively correlated (r = 0.24, P <0.01). ④ Conclusion There is a clear regional distribution of goiter and urinary iodine in the coastal areas of Shandong Province. The closer residents live from the sea, the higher the prevalence of goiter. Residents near the sea should be appropriately reduced iodine intake of substances.