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目的通过分析年龄、作业环境、电磁波辐射程度、噪声程度、应激紧张程度等因素对舰艇官兵细胞免疫功能的影响,明确导致舰艇官兵细胞免疫功能改变的具体因素。方法用流式细胞仪对247名舰艇官兵进行T、B、NK淋巴细胞亚群包括CD3+、CD3+CD4+、CD3+CD8+、CD4/CD8、CD3-CD19+和CD3-CD56+等6项免疫指标的检测,并按上述因素分组,进行统计学相关分析。结果不同年龄的舰艇官兵其细胞免疫功能无显著性差异(P>0.05);不同作业环境对机体CD3+、CD3+CD4+、CD3+CD8+、CD3-CD19+淋巴细胞均有一定影响;按电磁辐射程度分组,A组CD3+T淋巴细胞计数显著高于C组(P<0.05);其余各组免疫学指标则无统计学差异。按噪声程度分组,B、C两组CD3+T淋巴细胞低于A组(P<0.05);C组CD3+CD8+T淋巴细胞低于A组(P<0.05);B、C两组分别与A组比较,CD3-CD19+B淋巴细胞计数均显著增加(P<0.01)。按应激紧张程度进行分组,结果显示,与C组比较,B组CD3+T淋巴细胞和CD3-CD19+B淋巴细胞均增加(P<0.05)。结论年龄对舰艇官兵的细胞免疫功能无影响,作业环境、电磁辐射、噪声和应激紧张等因素对舰艇官兵的细胞免疫功能均有影响。
Objective To analyze the effects of age, working environment, degree of electromagnetic radiation, degree of noise, degree of stress and other factors on the cellular immune function of naval officers and soldiers and to clarify the specific factors that lead to the change of cellular immune function of naval officers and men. Methods Flow cytometry was used to detect T, B, NK lymphocyte subsets including 6 immune indexes of CD3 +, CD3 + CD4 +, CD3 + CD8 +, CD4 / CD8, CD3-CD19 + and CD3-CD56 + , And grouped by the above factors for statistical analysis. Results There were no significant differences in the cellular immune function between naval officers and men at different ages (P> 0.05). Different working environments had some effects on the CD3 +, CD3 +, CD4 +, CD3 + CD8 + and CD3-CD19 + , And the counts of CD3 + T lymphocytes in group A were significantly higher than those in group C (P <0.05). There was no significant difference in the immunological parameters among the other groups. The CD3 + T lymphocytes in groups B and C were lower than those in group A (P <0.05). The CD3 + CD8 + T lymphocytes in group C were lower than those in group A (P <0.05) Compared with group A, CD3-CD19 + B lymphocyte count increased significantly (P <0.01). Grouping according to the degree of stress, the results showed that compared with group C, CD3 + T lymphocytes and CD3-CD19 + B lymphocytes in group B were increased (P <0.05). Conclusions Age has no effect on the cellular immune function of naval officers and men. Operating environment, electromagnetic radiation, noise and stress stress have impact on the cellular immune function of naval officers and men.