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患儿,男性,2岁,因误服五氟利多24片(含20mg/片),十二小时后出现步态不稳.说活不清,嗜睡而急诊收住院。入院后检查;见典型锥体外系症状,表现为嗜睡,体态异常,斜颈,颈后屈,鬼脸,四肢、驱干冲击性及肌阵挛等。诊断:五氟利多中毒。处理:由于误服时间超过十二小时,故未洗胃,入院后主要采取输液、利尿及用苯海拉明对抗,二十四小时后开始啼哭,能唤醒并有吞咽动作。住院二天可进食,短暂下地活动。但仍嗜唾,加用利太林以提高兴奋性。住院六天,症状消失出院。讨论:①五氟利多为长效非镇静抗精神病药,主要副反应为锥体外系症状,且因胆碱能活性相对减低及纹状体黑质系统对多巴胺敏感则可出现迟发的
Children, male, 2 years old, because of oral administration of pentafluoridone 24 (including 20mg / tablets), twelve hours after the instability of gait, said indifferent, lethargy and emergency admission hospital. Admission examination; see the typical symptoms of extrapyramidal symptoms, manifested as lethargy, abnormal posture, torticollis, neck flexion, grimaces, limbs, dry shock and myoclonus. Diagnosis: Pentafluorosis poisoning. Treatment: due to the wrong time to serve more than twelve hours, it is not gastric lavage, mainly after admission to infusion, diuretic and diphenhydramine confrontation, twenty-four hours after crying can awaken and swallowing action. Two days hospital stay, short-term activities. But still addicted to saliva, add Li Tai Lin to increase excitability. Six days of hospitalization, the symptoms disappeared. Discussion: ① pentafluoridodine long-acting non-sedating antipsychotics, the main side effects of extrapyramidal symptoms, and because of the relative decrease in cholinergic activity and the striatum of the substantia nigra system is sensitive to dopamine may appear delayed