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目的 探讨肺炎支原体肺炎的发病机理，特别是与机体免疫功能紊乱的关系。方法对９０ 例住院的支原体肺炎患儿，根据其 Ｘ 线肺部受侵程度，分为重症组和轻症组，并设立了对照组，分别检测了各组极期和恢复期的 Ｔ 细胞亚群、血清可溶性白细胞介素－ ２ 受体（ Ｓ Ｉ Ｌ－ ２ Ｒ） 及天然杀伤细胞（ Ｎ Ｋ） 数。结果 肺炎支原体肺炎极期和恢复期 Ｃ Ｄ４ 均下降， Ｃ Ｄ８ 极期和恢复期均上升（ｔ ＝ ２ ．６３ ，２ ．６６ 和２ ．７７ ，３ ．３６ ， Ｐ＜ ０ ．０５） 。全部病人，无论极期还是恢复期 Ｓ Ｉ Ｌ－ ２ Ｒ 均显著高于正常，而在病的极期变化尤为明显（ｔ＝ ５ ．２６ ，３ ．１９ ， Ｐ＜ ０ ．０１） 。检测还显示： Ｓ Ｉ Ｌ－ ２ Ｒ 与病情有关，病情越重，增高越明显。结论 患支原体肺炎时存在细胞免疫功能紊乱，且检测 Ｓ Ｉ Ｌ－ ２ Ｒ 的水平可作为监测其严重程度的指标。流行病学资料表明发病年龄以１０ ～１４ 岁为多发。
Objective To explore the pathogenesis of Mycoplasma pneumoniae pneumonia, especially the relationship with immune dysfunction. Methods Totally 90 children with mycoplasmal pneumonia were divided into two groups: severe group and mild group according to the extent of X-ray lung invasion. A control group was set up to detect T cell subtypes in both polar phase and convalescent phase in each group Serum Soluble Interleukin - 2 Receptor (IL-2R) and Natural Killer Cell (NK) Numbers. Results Mycoplasma pneumonia pneumonia in both polar and convalescent C D4 decreased, C D8 polar period and convalescence increased (t = 2.63, 2.66 and 2.77, 3.36, P <0.05). All patients, both in very early and convalescent stages, were significantly higher than normal while the changes were most pronounced in the extreme (t = 5.226, 3.19, P <0.01). Test also showed: S I L-2 R with the disease, the more serious the disease, the more obvious increase. Conclusions Mycoplasma pneumonia is associated with cellular immune dysfunction, and the level of SI L-2R can be used as an indicator of its severity. Epidemiological data show that the onset of age to 10 to 14-year-old.