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目的探讨两种方案治疗慢性乙型病毒性肝炎合并酒精性肝损伤的效果。方法选取2011年7月至2014年7月慢性乙型病毒性肝炎合并酒精性肝损伤的患者80例,随机分为对照组和观察组,每组40例。对照组予以常规保肝治疗,观察组在对照组基础上加用复方二氯醋酸二异丙胺治疗,记录两组治疗前后肝功能指标的变化,评估临床疗效及不良反应。结果治疗有效率观察组为85.0%,对照组为65.0%,两组比较差异有统计学意义(P<0.05);治疗后观察组白蛋白、丙氨酶氨基转移酶、天门冬氨酸氨基转移酶、总胆红素分别为(36.32±9.51)g/L、(69.21±23.05)U/L、(37.32±12.65)U/L、(25.69±3.66)μmol/L,均低于对照组,差异有统计学意义(P<0.05)。结论复方二氯醋酸二异丙胺联合保肝治疗能够改善肝功能,有利于改善患者生活质量。
Objective To investigate the effect of two regimens in treating chronic hepatitis B with alcoholic liver injury. Methods From July 2011 to July 2014, 80 patients with chronic hepatitis B and alcoholic liver injury were randomly divided into control group and observation group, 40 cases in each group. The control group was treated with conventional liver protection. The observation group was treated with compound dichloroacetic acid diisopropylamine on the basis of the control group. The changes of liver function indexes before and after treatment were recorded and the clinical efficacy and adverse reactions were evaluated. Results The effective rate of treatment was 85.0% in the observation group and 65.0% in the control group, with significant difference between the two groups (P <0.05). After treatment, albumin, alanine aminotransferase, aspartate aminotransferase (36.32 ± 9.51) g / L, (69.21 ± 23.05) U / L, (37.32 ± 12.65) U / L and (25.69 ± 3.66) μmol / L respectively, which were lower than those of the control group The difference was statistically significant (P <0.05). Conclusion Compound dichloroacetic acid and diisopropylamine combined with hepatoprotective therapy can improve liver function and improve the quality of life of patients.