目的 :研究苦参碱对实验大鼠肝纤维化的防治作用 ,并探讨其可能的机制。方法 :应用四氯化碳诱导大鼠实验性肝纤维化 ,以苦参碱防治。观察3,6 ,12wk时溶剂对照组、四氯化碳组、苦参碱组血清丙氨酸转氨酶 (ALT)、透明质酸 (HA)、肝组织羟脯氨酸 (HyP)含量以及肝脏病理变化。结果 :苦参碱能显著减轻实验大鼠肝细胞变性、坏死及纤维组织的形成 ,同时能降低不同实验阶段血清ALT(P <0 .0 1) ,HA(P <0 .0 1)以及肝组织中HyP含量 (P <0 .0 5)。结论 :苦参碱有保护肝细胞 ,减轻肝细胞坏死 ,防治四氯化碳诱发的肝纤维化的作用。 Objective: To study the preventive and therapeutic effects of matrine on experimental liver fibrosis in rats and to explore its possible mechanism. METHODS: Rats with experimental liver fibrosis were induced with carbon tetrachloride and treated with matrine. Observe the contents of alanine aminotransferase (ALT), hyaluronic acid (HA), liver tissue hydroxyproline (HyP) and liver pathology in the solvent control group, carbon tetrachloride group, matrine group at 3, 6, and 12 wk Variety. RESULTS: Matrine could significantly reduce hepatocyte degeneration, necrosis, and fibrous tissue formation in experimental rats. At the same time, it could reduce serum ALT (P <0. 01), HA (P <0.01), and liver in different experimental phases. Tissue HyP content (P < 0.05). Conclusion: Matrine can protect liver cells, reduce liver cell necrosis, and prevent and treat carbon tetrachloride-induced hepatic fibrosis.