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为实施手术前后多种有效药物的个案化疗，并增加瘤段骨灭活的彻底性，缩短其术中灭活时间，本文进行了选择性个案化疗与瘤段骨超声灭活再植治疗骨肉瘤临床前瞻性随机对照研究。结果表明，观察组瘤段骨术中灭活时间明显缩短（约２０分钟），随访期内（２．５年）无瘤生存率（６５．０％）高于对照组［手术前后固定方案化疗加常规酒精灭活再植术（３３．３％）；经χ２检验Ｐ＜０．０５］。其术后合并症、局部复发及转移或死亡的发生率较对照组减低，但无统计学差异（Ｐ＞０．０５）；术后患肢功能评定结果两组间无差异。提示选择性个案化疗与瘤段骨超声灭活再植术是一种方法简便、疗效较好、经济节俭的骨肉瘤保肢综合治疗的有效方法之一。
In order to carry out chemotherapy for multiple effective drugs before and after surgery, and to increase the thoroughness of tumor bone inactivation and shorten the time of inactivation in the operation, this article has conducted selective case chemotherapy and ultrasonic replantation of tumor bone to treat osteosarcoma. Clinical prospective randomized controlled study. The results showed that the inactivation time was significantly shorter in the observation group (about 20 minutes), and the tumor-free survival rate (65.0%) was higher in the follow-up period (65 years) than in the control group. Plus conventional alcohol inactivation and replantation (33.3%); χ2 test P<0.05]. The incidence of postoperative complications, local recurrence and metastasis or death was lower than that of the control group, but there was no statistical difference (P>0.05). There was no difference between the two groups in postoperative limb function assessment results. It is suggested that selective chemotherapy and ultrasonic replantation of tumor segment bone are one of the effective methods for the comprehensive limb salvage treatment of osteosarcoma with simple method, good curative effect and economical economy.