细胞凋亡 (apoptosis)是机体为了维持自身稳定所采取的一种主动、积极的死亡方式。bcl- 2基因是一类癌基因 ,其家族成员形成同二聚体或异二聚体调节细胞凋亡 ,bcl- 2的过度表达与肿瘤的发生、发展密切相关。1　细胞凋亡1 972年 Kree等根据存在于许多正常组织中不完整细胞及细胞 Apoptosis (apoptosis) is the body to maintain its own stability taken by a proactive and positive way of death. The bcl-2 gene is a type of oncogene. Its family members form homodimers or heterodimers to regulate apoptosis. The overexpression of bcl-2 is closely related to tumorigenesis and development. 1 Apoptosis In 1997, Kree et al. Reported that incomplete cells and cells that exist in many normal tissues