临床用药中发现日、意两国头孢唑啉钠产品晶形不同。本实验对12名健康志愿受试者,肌注本品1.Og后,用生物法测试血浓度,并按单剂量血管外给药一室模型配置,分别获得不同晶形的同种药物动力学参数,结果表明其间无显著性差异。 Clinical medication found in Japan, Italy Cefazolin sodium crystal form. In this experiment, 12 healthy volunteers were intramuscularly injected with 1.0 g of this product, and the blood concentration was measured by the biological method. The single-dose intravascular administration of one-compartment model was used to obtain the same drug kinetics The results show that there is no significant difference between them.