An increasing variety of research practices are converging into information sci-ence mainstream — potentially. They are accompanied by astounding new uses of knowledge and even more astounding social transformations that revolve around information technolo-gies. Whether a robust information science will finally emerge may not only depend on suc-cessful discussions about the philosophy of information and the social impact of the new tech-nologies. The most important adjustment to make is about framing a“new way of thinking”within information science itself:an inner philosophy interconnecting research practices in fun-damental areas of the new science. Like in the historical birth of other major sciences,the em-pirical,comparative understanding of informational phenomena and informational entities should take place first. In the end,crafting a great scientific domain around information science should be a common ambition for all the scholars and researchers involved in these new stud-ies.