Two novel poly -oxygen bipyridine alkaloids, speranculatines A (1) and B (2) have been isolated from speranskia tuberculata. Their structures were elucidated by spectroscopic methods including 2D NMR techniques and X-ray crystallographic analysis. Two novel poly-oxygen bipyridine alkaloids, speranculatines A (1) and B (2) have been isolated from speranskia tuberculata. Their structures were elucidated by spectroscopic methods including 2D NMR techniques and X-ray crystallographic analysis.