目的　提高临床前原发性醛固酮增多症和临床前库兴综合征的诊治效果。　方法　回顾性总结 2 0例临床前原发性醛固酮增多症和临床前库兴综合征临床资料。　结果　临床前原发性醛固酮增多症 9例 ,血钾正常低值 5例 ,稍低于正常 3例 ,血醛固酮稍高于正常 4例 ,血浆肾素活性为正常低值 ,3例口服安体舒通治疗有效。临床前库兴综合征 11例 ,早 8时血皮醇增高 3例 ,下午 4时血皮质醇增高 4例 ,血ACTH检查 6例 ,为正常低值或稍低正常 ,3例大剂量地塞米松抑制试验 2例部分被抑制 ,术后临时激素替代疗法 4例。　结论　临床前原发性醛固酮增多症和临床前库兴综合征应根据各项检测结果综合分析作出诊断 ,对自主分泌或存在分泌潜能的肿瘤、≥ 2cm肿瘤和随诊中有增大趋势肿瘤应手术治疗 Objective To improve the diagnosis and treatment of preclinical aldosteronism and preclinical Cushing’s syndrome. Methods The clinical data of 20 pre-clinical primary aldosteronism and preclinical Cushing’s syndrome were retrospectively reviewed. Results 9 cases of pre-clinical primary aldosteronism, 5 cases of low normal serum potassium, slightly lower than normal in 3 cases, serum aldosteronism slightly higher than normal in 4 cases, plasma renin activity was normal low value, 3 cases of oral Antibody Shu Tong effective treatment. There were 11 cases of preclinical Cushing’s syndrome, 3 cases of hyperglycemia as early as 8 hours, 4 cases of elevated blood cortisol at 4:00 PM, 6 cases of ACTH test, which were normal low or normal, 3 cases of high dose of dexamethasone Misoprostol test 2 cases were inhibited, postoperative temporary hormone replacement therapy in 4 cases. Conclusion Pre-clinical primary aldosteronism and preclinical Cushing’s syndrome should be based on a comprehensive analysis of the test results to make a diagnosis, for the secretion of autologous secretion potential or existence of the tumor, ≥ 2cm tumor and follow-up have increased trend of tumor should Surgical treatment