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目的探讨蛋白激酶CK2-α′与涎腺腺样囊性癌(SACC)肺转移的关系。方法2008年4—7月于中国医科大学第一中心实验室,利用Western blotting方法对同一来源不同转移能力的SACC-83及SACC-LM细胞进行蛋白检测分析。结果蛋白激酶CK2-α′在两种细胞的细胞核中的表达都高于在细胞质中的表达;与SACC-83细胞相比,SACC-LM细胞的细胞核及细胞质中蛋白激酶CK2-α′均呈高表达。结论蛋白激酶CK2-α′的表达可能与涎腺腺样囊性癌的肺转移呈正相关。
Objective To investigate the relationship between protein kinase CK2-α ’and lung metastasis of salivary adenoid cystic carcinoma (SACC). Methods From April to July in 2008, the first central laboratory of China Medical University, western blotting was used to detect the protein of SACC-83 and SACC-LM cells with different metastasis potential from the same source. Results The expression of protein kinase CK2-α ’in the nucleus of both cells was higher than that in cytoplasm. Compared with SACC-83 cells, the protein kinase CK2-α’ in nuclei and cytoplasm of SACC-LM cells was High expression. Conclusion The expression of protein kinase CK2-α ’may be positively correlated with lung metastasis of salivary adenoid cystic carcinoma.