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已证实细胞因子及其受体的浓度可反映疟疾病理变化过程。作者通过检测3种细胞因子及其可溶性受体的水平以评价不同抗疟药治疗重症疟疾的效果。 在泰国东南部多重抗性恶性疟流行区春武里Phrapkklao医院收治的25例重症疟疾患者(男24,女1)列为试验对象。奎宁(Qn)组12例,蒿甲醚(ATM)组13例。其中脑型疟18例(每组9例),合并急性肾衰者10例,低血糖
The concentrations of cytokines and their receptors have been demonstrated to reflect the pathological changes in malaria. The authors evaluated the effect of different antimalarial drugs on severe malaria by measuring the levels of three cytokines and their soluble receptors. Twenty-five patients with severe malaria (male 24, female 1) admitted to Phrapkklao Hospital, Chonburi, in the multi-resistant falciparum malaria endemic area in southeastern Thailand were enrolled. Quinine (Qn) group of 12 cases, artemether (ATM) group of 13 cases. Including 18 cases of cerebral malaria (9 cases in each group), 10 cases of acute renal failure, hypoglycemia