论文部分内容阅读
目的 评价与比较米索前列醇 (Misoprostol,简称Miso)足月妊娠引产选择口服与阴道用药两种不同途径的效果及不良反应。方法 检索 1990年 1月至 2 0 0 2年 3月有关Miso引产的相关文献 10 8篇 ,筛选合格文献 ,提取数据资料 ,应用SAS中的meta分析软件包对各研究结果进行一致性检验和采用相应数学模型进行数据合并与分析。结果 符合入选标准的文献 7篇。从用药到阴道分娩的时间 5 0 μgMiso阴道用药组为 15 0h ,口服组为 2 0 4h ,合并估计的均数差为 - 0 4 6h (- 0 6 2h ,- 0 30h) ,P =0 0 11;宫缩异常两组的合并估计的率差为 11 3% (0 1% ,2 2 4 % ) ,P =0 0 4 7;新生儿窒息的合并估计的率差为1 92 % (- 0 5 7% ,4 4 % ) ,P =0 131。结论 米索前列醇足月妊娠引产中 ,阴道用药比口服用药的效率高 ,但宫缩异常发生率也较高 ,而新生儿结局差异无显著意义。
Objective To evaluate and compare the effects and adverse reactions of misoprostol (misoprostol, Miso) induced by labor during term pregnancy. Methods A total of 108 articles about Miso induction of labor from January 1990 to March 2002 were screened and qualified documents were screened. Data were extracted and meta-analysis software package of SAS was used to test the consistency of the findings. The corresponding mathematical model for data consolidation and analysis. The results meet the inclusion criteria of 7 articles. The time from administration to vaginal delivery was 150 μg for the vaginal group and 20 hours for the oral group. The estimated mean difference was -0.46 h (-0.62 h, -0.030 h), P = 0 0 11; the difference between the two groups was 11 3% (0 1%, 22 4%), P = 0 0 4 7; the rate of difference in the combined estimate of neonatal asphyxia was 1 92% (- 0 5 7%, 4 4%), P = 0 131. Conclusion Misoprostol in full-term pregnancy induction of labor, vaginal medication than oral medication efficiency, but the incidence of abnormal uterine contractions is also high, but no significant difference in neonatal outcomes.