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目的探讨与分析静滴硝酸甘油治疗冠心病性充血性心力衰竭的有效性与安全性。方法选取我院2015年1月至2017年1月收治的654例冠心病所致的充血性心力衰竭患者,根据不同患者采取不同的治疗方案,比较硝酸甘油的疗效及毒副作用。A组为硝酸甘油连续静滴,B组为硝酸甘油间歇治疗,两组均有强心、利尿、吸氧等常规治疗。结果心功能改善显著率分别为A组85.6%,B组100%,A组与B组差异有统计学意义(P<0.05)。A组、B组有效率均为100%,差异无统计学意义(P>0.05)。A组出现10例体位性低血压和晕厥,B组无严重不良反应。结论硝酸甘油静脉间歇给药治疗冠心病性充血性心力衰竭安全、有效、副作用小,具有临床使用价值。
Objective To investigate and analyze the efficacy and safety of intravenous nitroglycerin in the treatment of coronary heart disease with congestive heart failure. Methods A total of 654 CHD patients with congestive heart failure admitted to our hospital from January 2015 to January 2017 were enrolled in this study. The curative effect and side effects of nitroglycerin were compared according to different treatment options. A group of nitroglycerin continuous intravenous infusion, B group nitroglycerin intermittent treatment, both groups have cardiac, diuretic, oxygen and other conventional treatment. Results The improvement rates of cardiac function were 85.6% in group A and 100% in group B, respectively. The difference between group A and group B was statistically significant (P <0.05). The effective rates of group A and group B were 100%, with no significant difference (P> 0.05). A group of 10 cases of orthostatic hypotension and syncope, B group no serious adverse reactions. Conclusion Intermittent intravenous administration of nitroglycerin in the treatment of coronary heart disease with congestive heart failure is safe, effective and has few side effects and is of clinical value.