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目的:探讨围产期缺氧性脑损伤预后不良的早期预测方法。方法:对105例中重度围产期缺氧性脑损伤患儿进行回顾性分析,将43例有明显神经系统后遗症的患儿与62例无后遗症的患儿进行对照分析,选择18个可能的危险因素,先进行危险因素单因素分析,再经Logistic多元回归分析。结果18个可能的危险因素中有出生体重小于胎龄、神经症状出现于12 h之内、神经系统症状重出现抽搐或昏迷,此3个危险因素与以预后不良的发生具有明显的相关性(P<0.05)。结论综合分析围产儿缺氧后孕期体重增长情况、生后神经系统症状发生时间及惊厥或昏迷等重度脑损害症状发生情况,及时发现各项危险因素,进行重点干预,以早期预测神经系统后遗症,进行超早期治疗。
Objective: To investigate the early prediction method of poor prognosis of perinatal hypoxic brain injury. Methods: A retrospective analysis was performed in 105 children with moderate-to-severe perinatal hypoxic brain injury. Forty-three children with obvious neurological sequelae and 62 children without sequelae were analyzed. 18 possible Risk factors, the first risk factor univariate analysis, and then Logistic multiple regression analysis. Results Among the 18 possible risk factors, the birth weight was less than gestational age, neurological symptoms occurred within 12 hours, and the nervous system symptoms were convulsions or coma. These 3 risk factors were significantly associated with the poor prognosis ( P <0.05). Conclusions A comprehensive analysis of weight gain during pregnancy after hypoxia, the occurrence of post-natal nervous system symptoms, and the occurrence of severe brain injury symptoms such as seizures or coma, timely detection of various risk factors and focus intervention to early predict neurological sequelae, Ultra-early treatment.