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目的:研究黄酮类化合物杨梅酮对海马CA1区突触可塑性的影响。方法:采用立体定位仪固定大鼠头部,按照脑立体定位图谱确定刺激电极坐标和记录电极坐标,在体电生理技术检测海马CA1区长时程增强。结果:黄酮类化合物杨梅酮对强高频刺激(100 pulse 100Hz)诱导的长时程增强无显著影响;单独给予弱高频刺激(20 pulses 100 Hz)不能诱导出长时程增强,杨梅酮口服作用30 min后,应用该强度的弱刺激能够成功诱导出长时程增强。结论:黄酮类化合物杨梅酮能够易化弱高频刺激诱导出长时程增强现象,具有潜在的益智作用。
Objective: To study the effect of flavone on the synaptic plasticity of hippocampal CA1 region. Methods: The stereotaxic instrument was used to fix the head of rat and the stimulation electrode coordinate and recording electrode coordinate were determined according to stereotaxic map. The long-term potentiation of hippocampal CA1 region was detected by the electrophysiological technique. Results: Flavonoid myricetin had no significant effect on long-term potentiation induced by high frequency stimulation (100 pulse 100 Hz). Long-term enhancement was not induced by weak high frequency stimulation (20 pulses 100 Hz) After 30 minutes of action, weak stimulation of this intensity can successfully induce long-term potentiation. CONCLUSION: Flavonoid, myricetin, has the potential to be used as a puzzle because it facilitates the induction of long-term potentiation by weak high-frequency stimulation.