Background:The purpose of this study was to investigate the combined use of perfluorohexyloctane(F6H8) and 1 000-centistoke silicone oil as a long-term intraocular tamponade in the treatment of complicated retinal detachment.Methods:Sixty consecutive eyes affected by complicated retinal detachment with(1) retinal breaks of the lower two quadrants and severe proliferative vitreoretinopathy,(2) inferior giant retinal tear,(3) penetrating trauma or(4) choroidal detachment underwent pars plana vitrectomy using a combined internal tamponade of F6H8 and silicone oil.The double filling(DF) was removed after 40-50 days.The anatomical outcome and the complications due to the DF are reported.Results:Retinal reattachment was achieved in all but one patient.Thirty-eight(63%) eyes needed further surgery with silicone oil tamponade.Silicone oil was successfully removed in 22 eyes.Sixteen(27%) eyes had retained silicone oil at the last follow-up examination.One eye showed persistent retinal detachment despite further surgery.Main complications of the DF were recurrent retinal detachment of the upper retina in six(10%) eyes and membrane formation in 25(42%) eyes.Conclusions:A combined internal tamponade of F6H8 and silicone oil may be a useful tool in the treatment of complicated retinal detachment involving the lower quadrants of the retina. Background: The purpose of this study was to investigate the combined use of perfluorohexyloctane (F6H8) and 1 ’000-centistoke silicone oil as a long-term intraocular tamponade in the treatment of complicated retinal detachment. Methods: Sixty consecutive eyes affected by complicated retinal detachment with (1) retinal breaks of the lower two quadrants and severe proliferative vitreoretinopathy, (2) inferior giant retinal tear, (3) penetrating trauma or (4) choroidal detachment underwent pars plana vitrectomy using a combined internal tamponade of F6H8 and silicone oil The double filling (DF) was removed after 40-50 days. The anatomical outcome and the complications due to the DF are reported. Results: Retinal reattachment was achieved in all but one patient. Thirty-eight (63%) eyes needed further surgery with silicone oil tamponade.Silicone oil was successfully removed in 22 eyes.Sixteen (27%) eyes had retained silicone oil at the last follow-up examination .One eye showed persistent retinal detach ment despite further surgery. Main complications of the DF were recurrent retinal detachment of the upper retina in six (10%) eyes and membrane formation in 25 (42%) eyes. Conclusions: A combined internal tamponade of F6H8 and silicone oil may be a useful tool in the treatment of complicated retinal detachment involving the lower quadrants of the retina.