胎盘分泌多种激素,有的学者报告在脐带动静脉血中也发现了催产素,过去认为这是来自母体或胎儿垂体后叶的激素。近年来有关胎盘性催产素的问题特别引人注目,本文总结了最近的研究成果并加以讨论。 1.结构与免疫活性:将刮宫或分娩后去掉脐带、胎膜、蜕膜的胎盘组织片用生理盐水脱血,经醋酸提取法获得提取物,配成1∶1、1∶10、1∶100、的稀释倍数。放射免疫测定的结果,这个胎盘提取物的稀释曲线与合成催产素的剂量反应曲线在10～100pg/管的测定范围内基本一致。用抗催产素特异抗体的免疫亲合层析,胎盘提取物也显示类催产素的免疫活性。把胎盘提取物通过羧甲基纤维素 The placenta secretes a variety of hormones, and some scholars report that oxytocin has also been found in umbilical arteriovenous blood. In the past, this was thought to be a hormone derived from the mother or the fetus’s posterior pituitary. In recent years, the issue of placental oxytocin has drawn particular attention. This article summarizes and discusses the recent findings. 1. Structure and immunological activity: After the curettage or childbirth to remove the umbilical cord, fetal membranes, decidual placental tissue slices with physiological saline, obtained by acetic acid extraction extract, dubbed 1: 1, 1:10, 1: 100, the dilution factor. As a result of radioimmunoassay, the dilution curve of this placenta extract was in agreement with that of the synthetic oxytocin in the measurement range of 10 to 100 pg / tube. Placental extracts also show oxytocin immunosuppression with immunoaffinity chromatography of anti-oxytocin-specific antibodies. Placenta extract is passed through carboxymethylcellulose