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目的观察明胶海绵微球在经皮肝动脉化疗栓塞术(TACE)治疗肝癌的临床疗效和不良反应。方法对87例肝癌患者在肝动脉中灌注化疗药奥沙利铂、吡柔比星、5-氟尿嘧啶,并用碘油乳剂及明胶海绵微球进行联合栓塞,治疗后评价疗效及不良反应。结果 87例患者中完全缓解(CR)3例(3.5%),部分缓解(PR)55例(63.2%),稳定(SD)23例(26.4%),恶化(PD)6例(6.9%),总有效率为66.7%。主要不良反应为发热、恶心呕吐、白细胞减少及外周神经毒性,绝大多数为1~2级。结论应用明胶海绵微球在经皮肝动脉化疗栓塞术治疗肝癌的疗效显著,不良反应轻,值得临床推广应用。
Objective To observe the clinical efficacy and adverse reactions of gelatin sponge microspheres in transcatheter hepatic arterial chemoembolization (TACE) for liver cancer. Methods Eighty-seven patients with hepatocellular carcinoma were injected with oxaliplatin, pirarubicin, and 5-fluorouracil in the hepatic artery, and they were embolized with lipiodol emulsion and gelatin sponge microspheres. The efficacy and adverse reactions were evaluated after treatment. Results Among 87 patients, 3 were complete remission (CR) (3.5%), partial remission (PR) was 55 (63.2%), stable (SD) was 23 (26.4%), and deterioration (PD) was 6 (6.9%) The total effective rate is 66.7%. The main adverse reactions were fever, nausea, vomiting, leukopenia, and peripheral neurotoxicity. The vast majority were grade 1 to 2. Conclusion The application of gelatin sponge microspheres in the treatment of hepatocellular carcinoma by transcutaneous transcatheter arterial chemoembolization is effective and has mild adverse reactions. It is worthy of clinical application.