１引言 本世纪５０年代以前，治疗癫 主要药物是苯巴比妥和苯妥英，这和上个世纪仅有溴化钾相比有很大进步。本世纪近５０年来，抗癫药的研制得到了飞跃的发展，先后出现了扑米酮、乙琥胺、卡马西平、丙戊酸钠等有效的第一线药物，并有诸如乙酰唑胺、地西泮、氯硝西泮等第二线 1 Introduction Before the 1950s, phenobarbital and phenytoin were the main drugs for the treatment of epilepsy. This is a great improvement compared with potassium bromide only in the past century. In the recent 50 years, the development of antiepileptic drugs has been leapfrogged. First-line drugs such as primidone, ethosuximide, carbamazepine and sodium valproate have appeared in the first half of this century. Some drugs such as acetazolamide , Diazepam, clonazepam and other second-line