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目的分析新诊断的格雷夫斯(Graves)病患者肝功能与甲状腺激素及抗体水平的关系。方法对2002-09~2004-04南京市鼓楼医院117例新诊断的Graves病患者用抗甲亢药前,分析临床表现、肝功能、肝炎病毒指标、FT3、FT4、TSH、抗体TPOAb、TGAb、TRAb等。按肝功能正常与否分为正常组(74例)和异常组(39例),4例为病毒性肝炎予以剔除。结果113例新诊断的Graves病患者合并肝功能异常(至少有一项异常)的发生率34.51%。肝功异常组的FT3、FT4及TRAb水平明显高于肝功能正常组(P<0.001),而TSH、TPOAb、TGAb两组间无显著差异。结论新诊断的Graves病患者可出现由甲亢本身引起的肝功能受损,与患者的甲状腺激素水平、TRAb水平密切相关。伴有肝损的Graves病患者甲亢的病情较重。
Objective To analyze the relationship between liver function and thyroid hormones and antibody levels in newly diagnosed Graves’ disease. Methods The clinical manifestations, liver function, hepatitis virus index, FT3, FT4, TSH, antibodies TPOAb, TGAb and TRAb were analyzed in 117 newly diagnosed patients with Graves’ disease in Drum Tower Hospital, Nanjing, from September 2002 to April 2004. Wait. Divided into normal group (74 cases) and abnormal group (39 cases) according to whether liver function was normal or not, and 4 cases were excluded from viral hepatitis. Results The 113 newly diagnosed patients with Graves’ disease had 34.51% of patients with liver dysfunction (at least one abnormality). The levels of FT3, FT4 and TRAb in abnormal liver function group were significantly higher than those in normal liver function group (P <0.001), but there were no significant differences between TSH, TPOAb and TGAb groups. Conclusions Patients with newly diagnosed Graves’ disease may have impaired liver function caused by hyperthyroidism, which is closely related to thyroid hormone level and TRAb level. Patients with Graves’ disease who have liver damage have a higher prevalence of hyperthyroidism.