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目的探讨L-苹果酸对睡眠剥夺(SD)大鼠学习记忆的影响。方法 16只大鼠随机分为对照组(SD+生理盐水)和实验组(SD+L-苹果酸),用多平台水环境法建立大鼠SD模型,SD48h和SD72h后用Morris水迷宫测试大鼠的记忆能力。结果实验组大鼠的SD48h和SD72h水迷宫反应时均明显小于对照组。结论 L-苹果酸能改善睡眠剥夺的大鼠学习记忆能力。
Objective To investigate the effect of L-malic acid on learning and memory in sleep deprivation (SD) rats. Methods Sixteen rats were randomly divided into control group (SD + saline) and experimental group (SD + L-malic acid). SD rats were established by multi-platform water environment method. Rats were tested by Morris water maze after SD48h and SD72h Memory ability. Results The SD48h and SD72h water maze responses in experimental group were significantly less than those in control group. Conclusion L-malic acid can improve learning and memory ability of sleep deprived rats.