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目的:了解国产缓释型洛莫司汀(CCNU)的抗肿瘤特性.方法:利用国产CCNU为载体药.以PHB为基质,研制出的CCNU-PHB缓释体系应用于对人脑胶质瘤裸鼠局部化疗中.结果:CCNU 缓释膜的抗肿瘤效果与缓释膜中CCNU总量呈正相关.结论:缓释型CCNU对人脑胶质瘤瘤株裸鼠有显著疗效,疗效与缓释膜中CCNU总量呈正相关性.
Objective: To understand the antitumor properties of home-made sustained-release lomustine (CCNU). Method: Use domestic CCNU as carrier drug. Developed CCNU-PHB sustained-release system with PHB as a substrate for human glioma In local chemotherapy in nude mice. Results: The antitumor effect of CCNU sustained-release membrane was positively correlated with the total amount of CCNU in sustained-release membrane. Conclusion: Sustained-release CCNU has significant curative effect on human glioma tumor strain in nude mice. The total amount of CCNU in the film was positively correlated.