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作者研究了华山参(Physochlaina infundibularis Kuang)对中枢神经系统的药理作用.华山参煎剂腹腔注射对小白鼠的LD_(50)为43(28.7-64.5)克/公斤;腹腔注射1克/公斤使大白鼠防御运动性条件反射潜伏期延长,部分动物条件反射破坏及分化抑制有解除现象;灌胃给药(2克/公斤)仅使条件反射潜伏期延长.腹腔注射1-4克/公斤显著降低大、小白鼠和家兔的自由活动,维持3-6小时,但不降低小白鼠的被动活动.腹腔注射4克/公斤,能协同硫喷妥钠及水合氯醛对小白鼠的催眠、麻醉作用;降低苯丙胺、咖啡因对小白鼠的兴奋活动,但在10克/公斤时对本丙胺的毒性作用及士的宁,戊四唑性惊厥无影响.给狗灌胃2-5克/公斤,有明显的镇静作用,但不能对抗去水吗啡的催吐效果.
The author studied the pharmacological effects of Physalis infundibularis Kuang on the central nervous system.The LD 50 of Huashan ginseng decoction was 43 (28.7-64.5) g / kg for mice and 1 g / kg for intraperitoneal injection Rats with exercise-induced reflex latency prolonged, part of the animal reflex damage and the release of inhibition of the release phenomenon; intragastric administration (2 g / kg) only to prolong the conditioned reflex. Abdominal injection of 1-4 g / kg significantly reduced large , Free movement of mice and rabbits, maintaining 3-6 hours, but does not reduce the passive activity of mice.Intraperitoneal injection of 4 g / kg, in conjunction with thiopental and chloral hydrate mice hypnotic effects of anesthesia ; Reduce the amphetamine, caffeine on mice excited activity, but at 10 g / kg on the toxic effects of propylamine and strychnine, pentylenetetrazole seizures had no effect.Gastrointestinal feeding 2-5 g / kg, there Obvious sedative effect, but can not fight dehydrated morphine emetic effect.