Vatproate钠(VAL,二丙基醋酸钠,Depakene)是一种较新的抗癫痫药物,以往认为对典型失神发作(小发作)和强直——阵挛性发作最有效,但实际上对所有发作类型包括高热惊厥都有好处。最初,曾假设VAL抗癫痫作用的基础是抑制γ—氨酪酸转移酶(GABA—T)和丁醛酸脱氢酶(SuccinicSemialdehyde dehydroyenase,SSA—OH),从而使脑内 Vatproate sodium (VAL, Depakene) is a newer antiepileptic drug that was previously considered to be most effective in typical absence episodes (small seizures) and tonic-clonic seizures, but in fact for all seizures Types include febrile convulsions are good. Initially, it was hypothesized that the basis of VAL antiepileptic effects is the inhibition of GABA-T and SuccinicSemialdehyde dehydroxyenase (SSA-OH)