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目的对巴曲酶联合奥扎格雷钠治疗进展性脑梗死的疗效进行Meta分析,探讨此疗法的可行性和有效性。方法于万方数据库,以“巴曲酶”“奥扎格雷钠”“进展性脑梗死”作为检索关键词,检索2013年1月-2016年8月公开发表的有关于巴曲酶联合奥扎格雷钠治疗进展性脑梗死的相关文献,对检索出的文献进行分析,选取符合纳入标准的文献,对其进行Meta分析。结果符合纳入标准的相关文献共检索出5篇,均为奥扎格雷钠、奥扎格雷钠+巴曲酶对照研究,经Meta分析:奥扎格雷钠联合巴曲酶治疗组的临床疗效、神经功能缺损改善情况均优于单一奥扎格雷钠治疗组(P<0.05)。结论巴曲酶联合奥扎格雷钠治疗进展性脑梗死的临床疗效显著,优于单一奥扎格雷钠治疗。
Objective To evaluate the efficacy of batroxobin combined with ozagrel sodium in the treatment of patients with progressive cerebral infarction and to explore the feasibility and effectiveness of this therapy. Methods In the Wanfang database, using “Batroxobin” “ozagrel sodium” and “Progressive Cerebral Infarction” as search keywords, we searched the published data of January 2013 to August 2016 Batroxobin combined with ozagrel sodium in the treatment of progressive cerebral infarction related literature, the retrieved documents were analyzed, select the inclusion criteria of the literature, its meta-analysis. Results A total of 5 articles were retrieved, all of which were Ozagrel sodium and Ozagrel sodium + Batroxobin. Meta-analysis: The clinical efficacy of Ozagrel combined with Batroxobin, The improvement of functional impairment were better than single ozagrel sodium treatment group (P <0.05). Conclusion Batroxobin combined with ozagrel sodium in the treatment of progressive cerebral infarction was significantly better than the single ozagrel sodium treatment.