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目的研究粉尘所致肺病理损害程度的综合定量指标,评价不同游离SiO2含量的粉尘对肺组织的损害程度。方法依据形态计量学原理,用图像分析仪对动物尘肺模型肺组织切片的几种主要病变的面积进行测量,计算体密度和反映粉尘所致总的肺损害程度的定量指标———肺粉尘损害值(VPID);比较几种不同游离SiO2含量粉尘所致肺损害的程度。结果染尘时间相同的各组动物的某些尘肺病变的体密度之间差异有显著性(P<0.05);通过使用权重系数获得的VPID与粉尘游离iO2含量和全肺胶原含量之间均明显相关(r=0.535～0.849;P<0.05或P<0.01),VPID与此两者的相关程度都较未经权重的病变体密度简单相加之和为高。结论用VPID作为反映粉尘所致总的肺损害程度的综合定量指标合理、合适和简便;粉尘所致肺损害程度随粉尘中游离SiO2含量的升高而加重。
Objective To study the comprehensive quantitative index of the degree of pulmonary pathological damage caused by dust and to evaluate the degree of lung damage caused by dust with different free SiO2 content. Methods According to the principle of morphometry, the area of several main pathological changes in lung tissue sections of animal pneumoconiosis models were measured by image analyzer, and the body mass density and the quantitative index reflecting the degree of total lung damage caused by dust - lung dust damage Value (VPID); compare the degree of lung damage caused by several different free SiO2 content dusts. Results There was a significant difference (P <0.05) between the body density of some pneumoconiosis groups in the animals of the same dying time. The VPID obtained by using the weight coefficient was significantly different from that of the free iO2 content and the total lung collagen content (R = 0.535-0.849; P <0.05 or P <0.01). The correlation between VPID and these two factors was higher than the sum of the simple weight sum of diseased body weights. Conclusion VPID as a comprehensive quantitative index reflecting the degree of total lung damage caused by dust is reasonable, appropriate and simple. The degree of lung damage caused by dust increases with the increase of free SiO2 in dust.