论文部分内容阅读
目的探讨辛伐他汀对高胆固醇血症患者动脉弹性的影响。方法采用动脉弹性功能测定仪检测52例高胆固醇血症患者使用辛伐他汀前和使用4周后大动脉弹性(C1)、小动脉弹性(C2)和血浆总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)。结果用药4周后,TC和LDL-C均较用药前明显下降(均为P<0.01),C1和C2较用药前明显升高(均为P<0.01)。结论辛伐他汀可明显降低高胆固醇血症患者TC和LDL-C,同时显著改善动脉弹性。
Objective To investigate the effect of simvastatin on arterial elasticity in patients with hypercholesterolemia. Methods The arterial elasticity (C1), arteriolar elasticity (C2) and total cholesterol (TC), triglyceride (TG) and triglyceride (TG) were measured in 52 patients with hypercholesterolemia before and after using simvastatin ), High-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). Results After 4 weeks of treatment, TC and LDL-C were significantly lower than those before treatment (all P <0.01), while C1 and C2 were significantly higher than those before treatment (both P <0.01). Conclusion Simvastatin can significantly reduce the TC and LDL-C in patients with hypercholesterolemia, while significantly improving arterial elasticity.