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年龄对T细胞免疫反应的影响普遍存在的抗原引起的迟发型过敏反应随机体年龄的增长而下降。老化减低了人淋巴细胞对植物血凝素(PHA)的敏感性。最近的一些报告指出,老年人对淋巴细胞抗原和T细胞丝裂原的增殖反应下降。随着年龄的增长,C57BL/J小鼠对二硝基苯基化牛丙种球蛋白(一种T细胞高度依赖抗原)的脾细胞免疫反应数量进行性下降。不论原发反应还是继发反应,老化的动物(25月龄)主要丧失直接反应物质(IgG)和高亲和力空斑形成细胞,同时从细胞转化实验可以发现,这些动物的辅助细胞活性下降,而抑制细胞活性增强。因为T细胞在产生
Effects of Age on T Cell Immune Response Delayed allergic reactions caused by ubiquitous antigens are reduced as the body ages. Aging reduces the sensitivity of human lymphocytes to phytohemagglutinin (PHA). Recent reports indicate that the elderly have a decreased proliferative response to lymphocyte antigens and T-cell mitogen. With age, the number of immune responses to dinitrophenylated bovine gamma globulin, a highly T-dependent antigen, decreased in splenocytes in C57BL / J mice. Regardless of the primary or secondary reaction, aged animals (25 months old) mainly lost direct reactive substances (IgG) and high-affinity plaque-forming cells, and from the cell transformation experiments, the helper cell activity of these animals decreased Inhibit cell activity increased. Because T cells are producing