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目的探讨影响妊娠期糖尿病(GDM)的高危因素。方法回顾性分析2013年1月-2014年12月龙川县妇幼保健院妇产科11 119例孕妇的临床资料,其中GDM患者151例。分别采用Pearson单因素与多元Logistic回归分析法对影响GDM的高危因素进行分析。结果影响GDM的高危因素包括:年龄(β=0.420、SE=0.211、Wald值=8.227、P<0.05、OR=1.92、95%CI:1.39~2.27)、孕前体重指数(BMI)(β=0.518、SE=0.254、Wald值=9.017、P<0.05、OR=2.27、95%CI:1.95~2.65)、产前BMI(β=0.711、SE=0.365、Wald值=7.159、P<0.05、OR=2.07、95%CI:1.54~2.89)、孕期增重(β=0.526、SE=0.378、Wald值=7.653、P<0.05、OR=2.67、95%CI:1.65~3.37)、总胆固醇(CHOL)(β=0.459、SE=0.403、Wald值=9.187、P<0.05、OR=1.96、95%CI:1.73~2.23)、甘油三酯(TG)(β=0.652、SE=0.509、Wald值=9.231、P<0.01、OR=1.72、95%CI:1.56~2.18)、家族史(β=0.781、SE=0.433、Wald值=12.187、P<0.01、OR=2.01、95%CI:1.78~2.76)及孕次(β=0.627、SE=0.396、Wald值=10.172、P<0.01、OR=2.89、95%CI:2.45~3.28)。结论 GDM发病与年龄、孕前BMI、产前BMI、孕期增重、CHOL、TG、家族史及孕次等因素有关。因此,应注意对上述几种因素进行控制与观察,以有效降低GDM的临床发病率。
Objective To investigate the risk factors of gestational diabetes mellitus (GDM). Methods The clinical data of 11 119 pregnant women in obstetrics and gynecology department of Longchuan County Maternal and Child Health Hospital from January 2013 to December 2014 were retrospectively analyzed, including 151 GDM patients. Pearson single factor and multiple logistic regression analysis were used to analyze the risk factors of GDM. Results The high risk factors of GDM included age (β = 0.420, SE = 0.211, Wald value = 8.227, P <0.05, OR = 1.92, 95% CI: 1.39-2.77), pre-pregnancy body mass index , SE = 0.254, Wald value = 9.017, P <0.05, OR = 2.27, 95% CI: 1.95-2.65), prenatal BMI (β = 0.711, SE = 0.365, Wald value = 7.159, 2.07, 95% CI: 1.54-2.89), weight gain during pregnancy (β = 0.526, SE = 0.378, Wald value = 7.653, P 0.05, OR = 2.67, 95% CI 1.65-3.37) (β = 0.459, SE = 0.403, Wald = 9.187, P <0.05, OR = 1.96,95% CI: 1.73-2.23), triglycerides , Family history (β = 0.781, SE = 0.433, Wald value = 12.187, P <0.01, OR = 2.01, 95% CI: 1.78-2.76) And gestational age (β = 0.627, SE = 0.396, Wald value = 10.172, P <0.01, OR = 2.89, 95% CI: 2.45-3.28). Conclusions The incidence of GDM is related to age, pre-pregnancy BMI, prenatal BMI, weight gain during pregnancy, CHOL, TG, family history and pregnancy time. Therefore, we should pay attention to the above-mentioned several factors to control and observe, in order to effectively reduce the clinical incidence of GDM.