目的:探讨鼻内镜微创手术治疗鼻腔鼻窦恶性肿瘤的效果。方法:抽取2013年1月至2018年1月新乡市第二人民医院耳鼻喉外科收治的64例鼻腔鼻窦恶性肿瘤患者。根据手术方式不同将患者分为观察组(33例)和对照组(31例)。对照组采用传统鼻切开手术，观察组采用鼻内镜微创手术。观察两组手术情况，术后并发症以及术后1、2年随访生活质量和生存率。结果:观察组手术时间、术中出血量少于对照组(n P<0.05)。观察组并发症发生率15.15%(5/33)低于对照组并发症发生率38.71%(12/31)，n P<0.05。随访1、2年，观察组生理机能、生理职能、情感职能得分均高于对照组，且随访2年各项得分高于随访1年(n P<0.05)。观察组随访1年和2年年无复发生存率分别为90.91%、78.79%高于对照组的70.97%、54.84%(n P<0.05)。n 结论:微创手术治疗鼻腔鼻窦恶性肿瘤可有效减少手术时间及术中出血量，降低并发症发生率，提高患者术后生活质量和2年无复发生存率。“,”Objective:To explore the effect of endoscopic minimally invasive surgery in the treatment of malignant tumors of nasal cavity and paranasal sinuses.Methods:Sixty-four patients with sino-nasal neoplasm admitted to Second People’s Hospital of Xinxiang from January 2013 to January 2018 were divided into observation group (33 cases) and control group (31 cases) by different surgical methods. The control group received traditional rhinotomy and the observation group received minimally invasive surgery. The operation time, intraoperative blood loss, postoperative complications, and quality of life and survival rate after 1 year and 2 years of follow-up were recorded.Results:The operation time and intraoperative blood loss in the observation group were less than those in the control group (n P<0.05). The incidence of complications in the observation group was lower than that in the control group [15.15% (5/33)n vs. 38.71% (12/31), n P<0.05]. After 1 year and 2 years of follow-up, the physiological function, role physical, and role emotional scores were higher in observation group than in control group, and the scores of the 2-year follow-up were higher in observation group than the 1-year follow-up than those in controc group (n P<0.05). After 1-year and 2-year follow-up, the relapse-free survival rates in observation group were 90.91% and 78.79%, respectively, which were higher than those in the control group (70.97% and 54.84%),n P<0.05.n Conclusions:Minimally invasive surgery for sino-nasal neoplasm can effectively reduce the operation time and intraoperative blood loss, and the incidence of complications, and improve the postoperative quality of life and the 2-year recurrence-free survival rate.