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目的探讨阿奇霉素联合头孢呋辛治疗妊娠合并支原体衣原体感染的临床效果,为临床药物治疗提供依据。方法选取2015年1月至2016年1月于海口市妇幼保健院接受治疗的妊娠合并支原体衣原体感染孕妇400例。患者按入院先后顺序随机分为观察组(n=200)与对照组(n=200),对照组给予阿奇霉素治疗,观察组在对照组基础上联用头孢呋辛治疗。结果观察组治疗有效率为100.00%,明显高于对照组的68.50%,差异有统计学意义(P<0.05)。治疗后,观察组不良反应发生率为12.50%,对照组不良反应发生率为11.50%,两组不良反应差异无统计学意义(P>0.05)。观察组胎膜早破、产褥感染、低体重儿发生率明显低于对照组(P<0.05)。结论阿奇霉素联合头孢呋辛治疗妊娠合并支原体衣原体感染的临床效果显著,有利于改善妊娠结局,且不良反应发生率低。
Objective To investigate the clinical efficacy of azithromycin combined with cefuroxime in the treatment of chlamydial infection with mycoplasma in pregnancy and provide the basis for clinical drug therapy. Methods From January 2015 to January 2016, 400 pregnant women with mycoplasma chlamydia infection in pregnant women receiving pregnancy in Haikou MCH were selected. The patients were randomly divided into observation group (n = 200) and control group (n = 200) according to admission sequence. The control group was treated with azithromycin. The observation group was treated with cefuroxime on the basis of the control group. Results The effective rate of the observation group was 100.00%, which was significantly higher than that of the control group (68.50%), the difference was statistically significant (P <0.05). After treatment, the incidence of adverse reactions in the observation group was 12.50%, the incidence of adverse reactions in the control group was 11.50%. There was no significant difference in adverse reactions between the two groups (P> 0.05). Observation group of premature rupture of membranes, puerperal infection, low birth weight children was significantly lower than the control group (P <0.05). Conclusion The combination of azithromycin and cefuroxime in the treatment of Mycoplasma chlamydia infection in pregnancy has significant clinical effect, which is beneficial to improve pregnancy outcomes and the incidence of adverse reactions is low.