目的探讨β葡萄糖醛酸苷酶（βＧＤ）在母乳性黄疸发病中的作用。方法采用酶学比色法对４７例母乳性黄疸患儿及６０例正常新生儿粪便、血清及其母乳中βＧＤ活性浓度进行测定，并分析母乳性黄疸患儿βＧＤ活性浓度与血胆红素浓度的相关性。结果母乳性黄疸患儿母乳及粪便βＧＤ活性浓度分别为（１３６±０３０）Ｕ／Ｌ及（１０７±０３０）Ｕ／Ｌ，较正常新生儿［（０７５±０３３）Ｕ／Ｌ及（０５０±０２８）Ｕ／Ｌ］明显增高，二者之间差异有非常显著意义。患儿母乳及粪便βＧＤ活性浓度与血胆红素浓度呈明显正相关。黄疸消退期母乳及粪便βＧＤ活性浓度［（１１１±０３２）Ｕ／Ｌ及（０７２±０２６）Ｕ／Ｌ］较高峰期［（１３６±０３０）Ｕ／Ｌ及（１０７±０１０）Ｕ／Ｌ］明显降低，二者之间差异有非常显著意义。结论母乳及粪便βＧＤ活性浓度增高不仅与母乳性黄疸的发生有关，而且与其严重程度及病程经过密切相关。 Objective To investigate the role of β-glucuronidase (βGD) in the pathogenesis of breast milk jaundice. Methods The enzymatic colorimetric method was used to determine the βGD activity in 47 cases of breast milk jaundice and 60 normal newborn feces, serum and breast milk, and to analyze the βGD activity in breast milk in children with jaundice and blood Correlation of bilirubin concentrations. Results The breast milk and feces of breast milk jaundice β-GD activity concentrations were (1.36 ± 030) U / L and (1 07 ± 030) U / L, compared with normal neonates [(0  75 ± 033) U / L and (050 ± 028) U / L] were significantly increased, the difference between the two groups was significant. Breast milk and feces in children with β-GDP activity concentration and serum bilirubin concentration was positively correlated. Jaundiced breast milk and faeces excretion β  GD active concentration ((111 ± 032) U / L and (0  72 ± 0  26) U / L] peak (1  36  0  30 ) U / L and (107 ± 010) U / L] were significantly decreased, the difference between the two was significant. Conclusion The increase of βGD activity in breast milk and stool is not only related to the occurrence of breast milk jaundice, but also closely related to its severity and course.