论文部分内容阅读
目的 :半固态聚原酸酯是近来发展的一种新型聚原酸酯 ,具有许多新的特点 ,作为药物载体对其研究发展进行概述。方法 :对有关文献的分析 ,归纳总结了半固态聚原酸酯的特点、制备、理化性能、生物相容性、生物粘附性和应用。结果 :半固态聚原酸酯能够直接与药物混合 ,使药物释放体系制备过程简化 ,并具有良好的生物相容性和生物粘附性。结论 :半固态聚原酸酯是一种比较理想的药物释放载体。
Aim: Semi-solid polyorthoester is a new type of polyorthoester which has been developed recently. It has many new features and is an overview of its research and development as a drug carrier. Methods: Based on the analysis of relevant literatures, the characteristics, preparation, physical and chemical properties, biocompatibility, bioadhesion and application of semi-solid polyorthoester were summarized. Results: The semi-solid polyorthoester could be directly mixed with the drug, which simplified the preparation process of the drug delivery system and had good biocompatibility and bioadhesion. Conclusion: Semi-solid polyorthoester is an ideal drug delivery carrier.