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目的 :初步探讨骨桥蛋白 (Osteopontin ,OPN)与胃癌侵袭转移的关系。方法 :采用免疫组织化学SABC方法检测 12例非癌胃组织和 72例胃癌标本中OPN的表达及分布。结果 :(1) 12例非癌胃组织、30例无淋巴结转移和 2 6例有淋巴结转移及 16例有淋巴结转移且伴胃外器官转移的胃癌组织中 ,OPN的阳性表达率分别为 0、4 3 3% (13/30 )、76 92 % (2 0 /2 6 )和 87 5 % (14 /16 ) ;(2 )淋巴结转移伴有胃外器官转移和仅有淋巴结转移均与无淋巴结转移的胃癌组织中OPN的阳性表达率有明显差异 ,分别为 χ2 =8 396 ,P =0 0 0 4 ;χ2 =6 4 93,P =0 0 11。结论 :OPN与胃癌的侵袭转移密切相关 ,其分子机制需进一步研究
Objective: To investigate the relationship between osteopontin (OPN) and invasion and metastasis of gastric cancer. Methods: Immunohistochemical SABC method was used to detect the expression and distribution of OPN in 12 non-cancerous gastric tissues and 72 gastric cancer specimens. Results: (1) The positive expression rates of OPN in 12 cases of non-cancerous gastric tissue, 30 cases of non-lymph node metastasis and 26 cases of lymph node metastasis and 16 cases of gastric cancer with lymph node metastasis and extra-cellular organ metastasis were 0, (2) Lymph node metastasis accompanied with extra-gastric organ metastasis and only lymph node metastasis were associated with no lymph node metastasis The positive expression rates of OPN in metastatic gastric cancer tissues were significantly different, which were χ2 = 8 396, P = 0 044; χ2 = 6 4 93, P = 0 0 11, respectively. Conclusion: OPN is closely related to the invasion and metastasis of gastric cancer, and its molecular mechanism needs further study