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采用立体定位直流电损毁法，分别损毁双侧下丘、脑桥吻侧网状核、内侧膝状体、黑质，观察核团损毁对大鼠听源性惊厥行为的影响，以寻找与P77PMC大鼠听源性惊厥有关的神经核团。结果表明：双侧下丘损毁后能完全阻断强直阵挛性惊厥，脑桥吻侧网状核损毁能明显减少惊厥发生（P＜0．05），而双侧内侧膝状体及黑质损毁对惊厥无明显影响（P＜0．05）。提示下丘是P77PMC大鼠听源性惊厥的关键核团，而脑桥吻侧网状核可能参与了惊厥回路，内侧膝状体可能并未参与惊厥回路，黑质在此惊厥中的作用尚不明确。
Using stereotactic direct current destructive method, the bilateral inferior colliculus, the pyloric nucleus of the pontine, the medial geniculate nucleus and the substantia nigra were damaged, and the auditory convulsive behavior of the nucleus was observed in order to find out the relationship with the P77PMC rat Auditory convulsions-related neural nuclei. The results showed that the bilateral inferior colliculus could completely block the tonic clonic convulsion after the rupture of the inferior colliculus, and the destruction of the reticular nucleus of the kiss pontine of the ponsil could significantly reduce the occurrence of convulsion (P <0.05), while bilateral medial geniculate body and nigral lesion No significant effect on convulsion (P <0.05). Suggesting that the inferior colliculus is P77PMC rat auditory convulsions of the key nuclei, and the psoas muscle reticular nucleus may be involved in the convulsive circuit, the medial geniculate body may not participate in convulsions circuit, substantia nigra in this convulsion is not yet clear.